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Home - Products - GPCR/G Protein - Melanocortin Receptor - PG 931

PG 931

CAS No. 667430-81-1

PG 931( —— )

Catalog No. M30585 CAS No. 667430-81-1

Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PG 931
  • Note
    Research use only, not for human use.
  • Brief Description
    Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
  • Description
    Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
  • In Vitro
    ——
  • In Vivo
    PG-931 (intravenous?injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock. Animal Model:Wistar rats Dosage: 13-108 nmol/kg Administration:Intravenous?injection; single doseResult:Exhibitd an anti-shock effect occurred at nanomolar doses.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Melanocortin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    667430-81-1
  • Formula Weight
    1180.41
  • Molecular Formula
    C59H85N15O11
  • Purity
    >98% (HPLC)
  • Solubility
    25% ethanol / water:2 mg/mL
  • SMILES
    CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Giuliani et al (2007) Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br.J.Pharmacol. 150 595 PMID:
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